Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys

Protein tyrosine phosphatase (PTP)-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes. To date, studies of PTP-1B have been limited by the availability of specific antagonists; however, treatment of rodents with a...

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Main Authors: Swarbrick, Michael M., Havel, Peter J., Levin, Arthur A., Bremer, Andrew A., Stanhope, Kimber L., Butler, Madeline, Booten, Sheri L., Graham, James L., McKay, Robert A., Murray, Susan F., Watts, Lynnetta M., Monia, Brett P., Bhanot, Sanjay
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659262/
https://ncbi.nlm.nih.gov/pubmed/19164474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0885
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