Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys

Protein tyrosine phosphatase (PTP)-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes. To date, studies of PTP-1B have been limited by the availability of specific antagonists; however, treatment of rodents with a...

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Detaylı Bibliyografya
Asıl Yazarlar: Swarbrick, Michael M., Havel, Peter J., Levin, Arthur A., Bremer, Andrew A., Stanhope, Kimber L., Butler, Madeline, Booten, Sheri L., Graham, James L., McKay, Robert A., Murray, Susan F., Watts, Lynnetta M., Monia, Brett P., Bhanot, Sanjay
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Endocrine Society 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659262/
https://ncbi.nlm.nih.gov/pubmed/19164474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0885
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