Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

High affinity antisense oligonucleotides (ASOs) containing bicylic modifications (BNA) such as locked nucleic acid (LNA) designed to induce target RNA cleavage have been shown to have enhanced potency along with a higher propensity to cause hepatotoxicity. In order to understand the mechanism of thi...

詳細記述

保存先:
書誌詳細
出版年:Nucleic Acids Res
主要な著者: Burel, Sebastien A., Hart, Christopher E., Cauntay, Patrick, Hsiao, Jill, Machemer, Todd, Katz, Melanie, Watt, Andy, Bui, Huynh-hoa, Younis, Husam, Sabripour, Mahyar, Freier, Susan M., Hung, Gene, Dan, Amy, Prakash, T.P., Seth, Punit P., Swayze, Eric E., Bennett, C. Frank, Crooke, Stanley T., Henry, Scott P.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2016
主題:
Gene regulation, Chromatin and Epigenetics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797265/
https://ncbi.nlm.nih.gov/pubmed/26553810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1210
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料