Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

Reduction of matched and nearly complementary unintended transcripts was evaluated for 96 antisense oligonucleotides (ASOs) and 832 nearly matched unintended transcripts. The ASOs were 16–20 nucleotide “gapmers” with a gap of 8–10 DNA residues and 2′-O-methoxy-ethyl or constrained-ethyl substitution...

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Bibliografiske detaljer
Udgivet i:Nucleic Acid Ther
Main Authors: Watt, Andrew T., Swayze, Grant, Swayze, Eric E., Freier, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2020
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Original Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418465/
https://ncbi.nlm.nih.gov/pubmed/32125928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2020.0847
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