Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapm...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kasuya, Takeshi, Hori, Shin-ichiro, Watanabe, Ayahisa, Nakajima, Mado, Gahara, Yoshinari, Rokushima, Masatomo, Yanagimoto, Toru, Kugimiya, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961955/
https://ncbi.nlm.nih.gov/pubmed/27461380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30377
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