Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro cytotoxicity screens have not been reliable predi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Burdick, Andrew D., Sciabola, Simone, Mantena, Srinivasa R., Hollingshead, Brett D., Stanton, Robert, Warneke, James A., Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Makarov, Sergei S., Reed, Lori A., Davis, John W., Whiteley, Laurence O.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005641/
https://ncbi.nlm.nih.gov/pubmed/24550163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku142
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados