Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro cytotoxicity screens have not been reliable predi...

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Main Authors: Burdick, Andrew D., Sciabola, Simone, Mantena, Srinivasa R., Hollingshead, Brett D., Stanton, Robert, Warneke, James A., Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Makarov, Sergei S., Reed, Lori A., Davis, John W., Whiteley, Laurence O.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
主題:
Gene Regulation, Chromatin and Epigenetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005641/
https://ncbi.nlm.nih.gov/pubmed/24550163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku142
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