טוען...
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
A series of antisense oligonucleotides (ASOs) containing either 2′-O-methoxyethylribose (MOE) or locked nucleic acid (LNA) modifications were designed to investigate whether LNA antisense oligonucleotides (ASOs) have the potential to improve upon MOE based ASO therapeutics. Some, but not all, LNA co...
שמור ב:
| Main Authors: | , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1802611/ https://ncbi.nlm.nih.gov/pubmed/17182632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1071 |
| תגים: |
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