Design of antisense oligonucleotides stabilized by locked nucleic acids

The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates and 2′-O-methyl gapmers. In contradiction to the literature, a stretch of seven or eight DNA monomers in the center of a chimeric D...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Kurreck, Jens, Wyszko, Eliza, Gillen, Clemens, Erdmann, Volker A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11972327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.9.1911
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