Design of antisense oligonucleotides stabilized by locked nucleic acids

The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates and 2′-O-methyl gapmers. In contradiction to the literature, a stretch of seven or eight DNA monomers in the center of a chimeric D...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Kurreck, Jens, Wyszko, Eliza, Gillen, Clemens, Erdmann, Volker A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 2002
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11972327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.9.1911
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