Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro cytotoxicity screens have not been reliable predi...

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Autori principali: Burdick, Andrew D., Sciabola, Simone, Mantena, Srinivasa R., Hollingshead, Brett D., Stanton, Robert, Warneke, James A., Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Makarov, Sergei S., Reed, Lori A., Davis, John W., Whiteley, Laurence O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Gene Regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005641/
https://ncbi.nlm.nih.gov/pubmed/24550163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku142
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