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The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans
Systemically administered 2′-O-methoxyethyl (2′MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2′MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 and phase 3 trials. The principle analysis was on da...
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| Udgivet i: | Nucleic Acid Ther |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Mary Ann Liebert, Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5790433/ https://ncbi.nlm.nih.gov/pubmed/29185862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0693 |
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