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The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

Systemically administered 2′-O-methoxyethyl (2′MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2′MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 and phase 3 trials. The principle analysis was on da...

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Bibliografiske detaljer
Udgivet i:Nucleic Acid Ther
Main Authors: Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790433/
https://ncbi.nlm.nih.gov/pubmed/29185862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0693
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