Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans

Por Graham, Mark J., Viney, Nick, Crooke, Rosanne M., Tsimikas, Sotirios
Publicado no J Lipid Res (2016)

In Vivo Antisense Oligonucleotide Reduction of NPC1 Expression as a Novel Mouse Model for Niemann Pick Type C– Associated Liver Disease

Por Rimkunas, Victoria M., Graham, Mark J., Crooke, Rosanne M., Liscum, Laura
Publicado em 2008

TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease

Por Rimkunas, Victoria M., Graham, Mark J., Crooke, Rosanne M., Liscum, Laura
Publicado em 2009

Recovery from liver disease in a Niemann-Pick type C mouse model

Por Sayre, Naomi L., Rimkunas, Victoria M., Graham, Mark J., Crooke, Rosanne M., Liscum, Laura
Publicado em 2010

Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism

Por Li, Guoping, Hernandez-Ono, Antonio, Crooke, Rosanne M., Graham, Mark J., Ginsberg, Henry N.
Publicado em 2011

Antisense reduction of 11β-hydroxysteroid dehydrogenase type 1 enhances energy expenditure, and insulin sensitivity independent of food intake in C57BL/6J mice on a Western-type di...

Por Li, Guoping, Hernandez-Ono, Antonio, Crooke, Rosanne M., Graham, Mark J., Ginsberg, Henry N.
Publicado em 2011

Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics

Por Lee, Richard G., Crosby, Jeff, Baker, Brenda F., Graham, Mark J., Crooke, Rosanne M.
Publicado em 2013

Evaluation of an Anti-Tumor Necrosis Factor Therapeutic in a Mouse Model of Niemann-Pick C Liver Disease

Por Vincent, Melanie, Sayre, Naomi L., Graham, Mark J., Crooke, Rosanne M., Shealy, David J., Liscum, Laura
Publicado em 2010

CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation

Por Donner, Aaron J, Yeh, Steve T, Hung, Gene, Graham, Mark J, Crooke, Rosanne M, Mullick, Adam E
Publicado no Mol Ther Nucleic Acids (2015)

Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice

Por Carr, Rotonya M., Patel, Rajesh T., Rao, Vandana, Dhir, Ravindra, Graham, Mark J., Crooke, Rosanne M., Ahima, Rexford S.
Publicado em 2012

Lowering apolipoprotein CIII delays onset of type 1 diabetes

Por Holmberg, Rebecka, Refai, Essam, Höög, Anders, Crooke, Rosanne M., Graham, Mark, Olivecrona, Gunilla, Berggren, Per-Olof, Juntti-Berggren, Lisa
Publicado em 2011

Antisense oligonucleotide inhibition of cholesteryl ester transfer protein enhances RCT in hyperlipidemic, CETP transgenic, LDLr(−/−) mice

Por Bell, Thomas A., Graham, Mark J., Lee, Richard G., Mullick, Adam E., Fu, Wuxia, Norris, Dan, Crooke, Rosanne M.
Publicado em 2013

Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice

Por Mullick, Adam E., Fu, Wuxia, Graham, Mark J., Lee, Richard G., Witchell, Donna, Bell, Thomas A., Whipple, Charles P., Crooke, Rosanne M.
Publicado em 2011

Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice

Por Xie, Yan, Fung, Ho Yee Joyce, Newberry, Elizabeth P., Kennedy, Susan, Luo, Jianyang, Crooke, Rosanne M., Graham, Mark J., Davidson, Nicholas O.
Publicado em 2014

Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp (−/−) mice

Por Newberry, Elizabeth P., Kennedy, Susan M., Xie, Yan, Luo, Jianyang, Crooke, Rosanne M., Graham, Mark J., Fu, Jin, Piomelli, Daniele, Davidson, Nicholas O.
Publicado em 2012

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Por Lee, Richard G., Fu, Wuxia, Graham, Mark J., Mullick, Adam E., Sipe, Donna, Gattis, Danielle, Bell, Thomas A., Booten, Sheri, Crooke, Rosanne M.
Publicado em 2013

Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers

Por Noveck, Robert, Stroes, Erik S. G., Flaim, JoAnn D., Baker, Brenda F., Hughes, Steve, Graham, Mark J., Crooke, Rosanne M., Ridker, Paul M
Publicado no J Am Heart Assoc (2014)

Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in Liver fatty acid binding protein null mice

Por Newberry, Elizabeth P., Xie, Yan, Kennedy, Susan M., Graham, Mark J., Crooke, Rosanne M., Jiang, Hui, Chen, Anping, Ory, Daniel S., Davidson, Nicholas O.
Publicado no Hepatology (2017)

Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits

Por Yu, Qi, Liu, Zhengcao, Waqar, Ahmed Bilal, Ning, Bo, Yang, Xianghong, Shiomi, Masashi, Graham, Mark J., Crooke, Rosanne M., Liu, Enqi, Dong, Sijun, Fan, Jianglin
Publicado em 2014

The Role of Insulin in the Regulation of PCSK9

Por Miao, Ji, Manthena, Praveen V., Haas, Mary E., Ling, Alisha V., Shin, Dong-Ju, Graham, Mark J., Crooke, Rosanne M., Liu, Jingwen, Biddinger, Sudha B.
Publicado no Arterioscler Thromb Vasc Biol (2015)