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Evaluation of an Anti-Tumor Necrosis Factor Therapeutic in a Mouse Model of Niemann-Pick C Liver Disease

BACKGROUND: Niemann-Pick type C (NPC) disease is a lysosomal storage disease characterized by the accumulation of cholesterol and glycosphingolipids. The majority of NPC patients die in their teen years due to progressive neurodegeneration; however, half of NPC patients also suffer from cholestasis,...

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Hlavní autoři: Vincent, Melanie, Sayre, Naomi L., Graham, Mark J., Crooke, Rosanne M., Shealy, David J., Liscum, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944848/
https://ncbi.nlm.nih.gov/pubmed/20886067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012941
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