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TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease
Niemann-Pick type C (NPC) is a fatal autosomal recessive lysosomal storage disease clinically characterized by neurodegeneration and liver disease. Heterogeneous mutations in the NPC1 and NPC2 genes cause impaired egress of free cholesterol from lysosomes, leading to accumulation of cholesterol and...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636917/ https://ncbi.nlm.nih.gov/pubmed/18815434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800415-JLR200 |
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