Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Therapeutic agents that suppress apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who are unable to reach target LDL-C levels with maximally tolerated lipid-lowering drugs. To compare and contrast the met...

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Detalhes bibliográficos
Main Authors: Lee, Richard G., Fu, Wuxia, Graham, Mark J., Mullick, Adam E., Sipe, Donna, Gattis, Danielle, Bell, Thomas A., Booten, Sheri, Crooke, Rosanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617936/
https://ncbi.nlm.nih.gov/pubmed/23220583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M029215
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