Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice

Chronic elevations of plasma apolipoprotein B (apoB) are strongly associated with cardiovascular disease. We have previously demonstrated that inhibition of hepatic apoB mRNA using antisense oligonucleotides (ASO) results in reductions of apoB, VLDL, and LDL in several preclinical animal models and...

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Detalhes bibliográficos
Main Authors: Mullick, Adam E., Fu, Wuxia, Graham, Mark J., Lee, Richard G., Witchell, Donna, Bell, Thomas A., Whipple, Charles P., Crooke, Rosanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073476/
https://ncbi.nlm.nih.gov/pubmed/21343632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M011791
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