Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice

Chronic elevations of plasma apolipoprotein B (apoB) are strongly associated with cardiovascular disease. We have previously demonstrated that inhibition of hepatic apoB mRNA using antisense oligonucleotides (ASO) results in reductions of apoB, VLDL, and LDL in several preclinical animal models and...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Mullick, Adam E., Fu, Wuxia, Graham, Mark J., Lee, Richard G., Witchell, Donna, Bell, Thomas A., Whipple, Charles P., Crooke, Rosanne M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2011
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073476/
https://ncbi.nlm.nih.gov/pubmed/21343632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M011791
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky