CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation

Preclinical and clinical data suggest CD40 activation contributes to renal inflammation and injury. We sought to test whether upregulation of CD40 in the kidney is a causative factor of renal pathology and if reduction of renal CD40 expression, using antisense oligonucleotides (ASOs) targeting CD40,...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Donner, Aaron J, Yeh, Steve T, Hung, Gene, Graham, Mark J, Crooke, Rosanne M, Mullick, Adam E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014534/
https://ncbi.nlm.nih.gov/pubmed/26623936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.40
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