Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity

Por KRAYNACK, BRYAN A., BAKER, BRENDA F.
Publicado em 2006

Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro(®)): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B

Por Geary, Richard S., Baker, Brenda F., Crooke, Stanley T.
Publicado no Clin Pharmacokinet (2015)

Phosphorothioate Antisense Oligonucleotides Induce the Formation of Nuclear Bodies

Por Lorenz, Peter, Baker, Brenda F., Bennett, C. Frank, Spector, David L.
Publicado em 1998

Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides

Por Lorenz, Peter, Misteli, Tom, Baker, Brenda F., Bennett, C. Frank, Spector, David L.
Publicado em 2000

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

Por Hua, Yimin, Vickers, Timothy A, Baker, Brenda F, Bennett, C. Frank, Krainer, Adrian R
Publicado em 2007

Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics

Por Lee, Richard G., Crosby, Jeff, Baker, Brenda F., Graham, Mark J., Crooke, Rosanne M.
Publicado em 2013

Changes in Mipomersen Dosing Regimen Provide Similar Exposure With Improved Tolerability in Randomized Placebo‐Controlled Study of Healthy Volunteers

Por Flaim, JoAnn D., Grundy, John S., Baker, Brenda F., McGowan, Mary P., Kastelein, John J. P.
Publicado em 2014

Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers

Por Noveck, Robert, Stroes, Erik S. G., Flaim, JoAnn D., Baker, Brenda F., Hughes, Steve, Graham, Mark J., Crooke, Rosanne M., Ridker, Paul M
Publicado no J Am Heart Assoc (2014)

The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

Por Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Publicado no Nucleic Acid Ther (2017)

A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

Por Jones, Nicholas R, Pegues, Melissa A, McCrory, Mark A, Singleton, Walter, Bethune, Claudette, Baker, Brenda F, Norris, Daniel A, Crooke, Rosanne M, Graham, Mark J, Szalai, Alexander J
Publicado em 2012

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Por Crooke, Stanley T, Baker, Brenda F, Kwoh, T Jesse, Cheng, Wei, Schulz, Dan J, Xia, Shuting, Salgado, Nelson, Bui, Huynh-Hoa, Hart, Christopher E, Burel, Sebastien A, Younis, Husam S, Geary, Richard S, Henry, Scott P, Bhanot, Sanjay
Publicado no Mol Ther (2016)

Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-control...

Por Visser, Maartje E., Wagener, Gilbert, Baker, Brenda F., Geary, Richard S., Donovan, Joanne M., Beuers, Ulrich H.W., Nederveen, Aart J., Verheij, Joanne, Trip, Mieke D., Basart, Dick C.G., Kastelein, John J.P., Stroes, Erik S.G.
Publicado em 2012