Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures

Nuclear paraspeckles are built co-transcriptionally around a long non-coding RNA, NEAT1. Here we report that transfected 20-mer phosphorothioate-modified (PS) antisense oligonucleotides (ASOs) can recruit paraspeckle proteins to form morphologically normal and apparently functional paraspeckle-like...

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Hlavní autoři: Shen, Wen, Liang, Xue-hai, Crooke, Stanley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117792/
https://ncbi.nlm.nih.gov/pubmed/25013176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku579
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