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Inhibitor-induced structural change in the HCV IRES domain IIa RNA

Translation of the hepatitis C virus (HCV) RNA is initiated from a highly structured internal ribosomal entry site (IRES) in the 5′ untranslated region (5′ UTR) of the RNA genome. An important structural feature of the native RNA is an approximately 90° helical bend localized to domain IIa that posi...

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Hlavní autoři: Paulsen, Ryan B., Seth, Punit P., Swayze, Eric E., Griffey, Richard H., Skalicky, Jack J., Cheatham, Thomas E., Davis, Darrell R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867761/
https://ncbi.nlm.nih.gov/pubmed/20360559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911896107
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