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Regulation of PKR by HCV IRES RNA: Importance of Domain II and NS5A
The protein kinase PKR is an essential component of the innate immune response. In the presence of dsRNA, PKR is autophosphorylated, which enables it to phosphorylate its substrate, eIF2α, leading to translation cessation. Typical activators of PKR are long dsRNAs produced during viral infection, al...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902579/ https://ncbi.nlm.nih.gov/pubmed/20447405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.059 |
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