Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleo...

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Detalhes bibliográficos
Main Authors: Nallagatla, Subba Rao, Jones, Christie N., Ghosh, Saikat Kumar B., Sharma, Suresh D., Cameron, Craig E., Spremulli, Linda L., Bevilacqua, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587421/
https://ncbi.nlm.nih.gov/pubmed/23483938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057905
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