Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleo...

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Hlavní autoři: Nallagatla, Subba Rao, Jones, Christie N., Ghosh, Saikat Kumar B., Sharma, Suresh D., Cameron, Craig E., Spremulli, Linda L., Bevilacqua, Philip C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587421/
https://ncbi.nlm.nih.gov/pubmed/23483938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057905
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