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Conformational inhibition of the HCV IRES RNA
The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770845/ https://ncbi.nlm.nih.gov/pubmed/19767736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.217 |
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