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Functional conservation despite structural divergence in ligand-responsive RNA switches
An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive conformational switches in viral IRES elements. Modular RNA motifs of greatly distinct sequence and local secondary structure have been found...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234586/ https://ncbi.nlm.nih.gov/pubmed/25349403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414678111 |
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