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Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches

The internal ribosome entry site (IRES) in the hepatitis C virus (HCV) RNA genome is essential for the initiation of viral protein synthesis. IRES domains adopt well-defined folds that are potential targets for antiviral translation inhibitors. We have determined the three-dimensional structure of t...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Dibrov, Sergey M., Ding, Kejia, Brunn, Nicholas D., Parker, Matthew A., Bergdahl, B. Mikael, Wyles, David L., Hermann, Thomas
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325719/
https://ncbi.nlm.nih.gov/pubmed/22431596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118699109
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