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Conformational inhibition of the HCV IRES RNA

The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES...

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Bibliografski detalji
Glavni autori: Parsons, Jerod, Castaldi, M. Paola, Dutta, Sanjay, Dibrov, Sergey M., Wyles, David L., Hermann, Thomas
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770845/
https://ncbi.nlm.nih.gov/pubmed/19767736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.217
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