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Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter
RNAi using single-strand RNA would provide new options for therapeutic development and for investigating critical questions of mechanism. Using chemically modified single-strands we test the hypothesis that single-stranded RNAs can engage the RNAi pathway and silence gene transcription. We find that...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3909965/ https://ncbi.nlm.nih.gov/pubmed/23082936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300490j |
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