A Novel M(1) PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Selective activation of the M(1) subtype of muscarinic acetylcholine receptor, via positive allosteric modulation (PAM), is an exciting strategy to improve cognition in schizophrenia and Alzheimer’s disease patients. However, highly potent M(1) ago-PAMs, such as MK-7622, PF-06764427, and PF-06827443...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Neurosci
Prif Awduron: Rook, Jerri M., Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Moran, Sean P., Maksymetz, James T., Nance, Kellie D., Dickerson, Jonathan W., Remke, Daniel H., Chang, Sichen, Harp, Joel M., Blobaum, Anna L., Niswender, Colleen M., Jones, Carrie K., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146057/
https://ncbi.nlm.nih.gov/pubmed/29701957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00131
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