A Novel M(1) PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Selective activation of the M(1) subtype of muscarinic acetylcholine receptor, via positive allosteric modulation (PAM), is an exciting strategy to improve cognition in schizophrenia and Alzheimer’s disease patients. However, highly potent M(1) ago-PAMs, such as MK-7622, PF-06764427, and PF-06827443...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Rook, Jerri M., Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Moran, Sean P., Maksymetz, James T., Nance, Kellie D., Dickerson, Jonathan W., Remke, Daniel H., Chang, Sichen, Harp, Joel M., Blobaum, Anna L., Niswender, Colleen M., Jones, Carrie K., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146057/
https://ncbi.nlm.nih.gov/pubmed/29701957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00131
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