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Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine

Like the other Y-family DNA polymerases, human DNA polymerase η (hpol η) has relatively low fidelity and is able to tolerate damage during DNA synthesis, including 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), one of the most abundant DNA lesions in the genome. Crystal structures show that Arg-61 an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Su, Yan, Patra, Amritraj, Harp, Joel M., Egli, Martin, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481197/
https://ncbi.nlm.nih.gov/pubmed/25947374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653691
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