Molecular imaging probe development: a chemistry perspective

Por Nolting, Donald D, Nickels, Michael L, Guo, Ning, Pham, Wellington
Publicado em 2012

New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO

Por Li, Jun, Schulte, Michael L., Nickels, Michael L., Manning, H. Charles
Publicado no Bioorg Med Chem Lett (2016)

Automated Radiosynthesis of 5-[(11)C]L-Glutamine, an Important Tracer for Glutamine Utilization

Por Rosenberg, Adam J., Nickels, Michael L., Schulte, Michael L., Manning, H. Charles
Publicado no Nucl Med Biol (2018)

Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazino...

Por Cheung, Yiu-Yin, Nickels, Michael L., Tang, Dewei, Buck, Jason R., Manning, H. Charles
Publicado em 2014

Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([(18)F]VUIIS1008) in...

Por Tang, Dewei, Nickels, Michael L., Tantawy, M. Noor, Buck, Jason R., Manning, H. Charles
Publicado no Mol Imaging Biol (2014)

Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[(18)F]Fluoroethoxy) phenyl)-5-Methylpyrazolo[1,5-a] Pyrimidin-3-yl)-N,N-Diethylacetamide ((18)F-VUIIS1018A) to...

Por Tang, Dewei, Li, Jun, Nickels, Michael L., Huang, Gang, Cohen, Allison S., Manning, H. Charles
Publicado no Mol Imaging Biol (2019)

High-yielding, automated production of 3′-deoxy-3′-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module

Por Cheung, Yiu-Yin, Nickels, Michael L., McKinley, Eliot T., Buck, Jason R., Manning, H. Charles
Publicado no Appl Radiat Isot (2014)

N-[(18)F]-Fluoroacetylcrizotinib: A Potentially Potent and Selective PET Tracer for Molecular Imaging of Non–small Cell Lung Cancer

Por Buck, Jason R., Saleh, Samir, Claus, Trey, Lovly, Christine, Hight, Matthew R., Nickels, Michael L., Tantawy, M. Noor, Manning, H. Charles
Publicado no Bioorg Med Chem Lett (2020)

Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging

Por Tang, Dewei, Li, Jun, Buck, Jason R., Tantawy, Mohamed Noor, Xia, Yan, Harp, Joel M., Nickels, Michael L., Meiler, Jens, Manning, H. Charles
Publicado no Mol Imaging Biol (2017)

Synthesis and Structure-Activity Relationships of 5,6,7-substituted Pyrazolopyrimidines: Discovery of a novel TSPO PET Ligand for Cancer Imaging

Por Tang, Dewei, McKinley, Eliot T., Hight, Matthew R., Uddin, Md. Imam, Harp, Joel M., Fu, Allie, Nickels, Michael L., Buck, Jason R., Manning, H. Charles
Publicado em 2013

Preclinical Evaluation of 4-[(18)F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer

Por Hassanein, Mohamed, Hight, Matthew R., Buck, Jason R., Tantawy, Mohammed N., Nickels, Michael L., Hoeksema, Megan D., Harris, Bradford K., Boyd, Kelli, Massion, Pierre P., Manning, H. Charles
Publicado no Mol Imaging Biol (2016)

A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells

Por Hight, Matthew R., Cheung, Yiu-Yin, Nickels, Michael L., Dawson, Eric S., Zhao, Ping, Saleh, Samir, Buck, Jason R., Tang, Dewei, Washington, M. Kay, Coffey, Robert J., Manning, H. Charles
Publicado em 2014

Utility of [(18)F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population

Por Kavanaugh, Gina, Williams, Jason, Morris, Andrew Scott, Nickels, Michael L., Walker, Ronald, Koglin, Norman, Stephens, Andrew W., Washington, M. Kay, Geevarghese, Sunil K., Liu, Qi, Ayers, Dan, Shyr, Yu, Manning, H. Charles
Publicado no Mol Imaging Biol (2016)

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Por Luo, Na, Nixon, Mellissa J., Gonzalez-Ericsson, Paula I., Sanchez, Violeta, Opalenik, Susan R., Li, Huili, Zahnow, Cynthia A., Nickels, Michael L., Liu, Fei, Tantawy, Mohammed N., Sanders, Melinda E., Manning, H. Charles, Balko, Justin M.
Publicado no Nat Commun (2018)

Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults

Por Smith, Christopher T., San Juan, M. Danica, Dang, Linh C., Katz, Daniel T., Perkins, Scott F., Burgess, Leah L., Cowan, Ronald L., Manning, H. Charles, Nickels, Michael L., Claassen, Daniel O., Samanez-Larkin, Gregory R., Zald, David H.
Publicado no Transl Psychiatry (2018)

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer

Por Uddin, Md. Jashim, Wilson, Andrew J., Crews, Brenda C., Malerba, Paola, Uddin, Md. Imam, Kingsley, Philip J., Ghebreselasie, Kebreab, Daniel, Cristina K., Nickels, Michael L., Tantawy, Mohammed N., Jashim, Elma, Manning, H. Charles, Khabele, Dineo, Marnett, Lawrence J.
Publicado no ACS Omega (2019)

Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models

Por Schulte, Michael L., Fu, Allie, Zhao, Ping, Li, Jun, Geng, Ling, Smith, Shannon T., Kondo, Jumpei, Coffey, Robert J., Johnson, Marc O., Rathmell, Jeffrey C., Sharick, Joe T., Skala, Melissa C., Smith, Jarrod A., Berlin, Jordan, Washington, M. Kay, Nickels, Michael L., Manning, H. Charles
Publicado no Nat Med (2018)