Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

GABA(A) receptors form Cl(−) permeable channels that mediate the majority of fast synaptic inhibition in the brain. The K(+)/Cl(−) cotransporter KCC2 is the main mechanism by which neurons establish low intracellular Cl(−) levels, which is thought to enable GABAergic inhibitory control of neuronal a...

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Pubblicato in:J Neurosci
Autori principali: Sivakumaran, Sudhir, Cardarelli, Ross A., Maguire, Jamie, Kelley, Matt R., Silayeva, Liliya, Morrow, Danielle H., Mukherjee, Jayanta, Moore, Yvonne E., Mather, Robert J., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Zicha, Stephen, Moss, Stephen J., Deeb, Tarek Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444547/
https://ncbi.nlm.nih.gov/pubmed/26019342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5205-14.2015
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