Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

GABA(A) receptors form Cl(−) permeable channels that mediate the majority of fast synaptic inhibition in the brain. The K(+)/Cl(−) cotransporter KCC2 is the main mechanism by which neurons establish low intracellular Cl(−) levels, which is thought to enable GABAergic inhibitory control of neuronal a...

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Publicat a:J Neurosci
Autors principals: Sivakumaran, Sudhir, Cardarelli, Ross A., Maguire, Jamie, Kelley, Matt R., Silayeva, Liliya, Morrow, Danielle H., Mukherjee, Jayanta, Moore, Yvonne E., Mather, Robert J., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Zicha, Stephen, Moss, Stephen J., Deeb, Tarek Z.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
Matèries:
Brief Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444547/
https://ncbi.nlm.nih.gov/pubmed/26019342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5205-14.2015
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