Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

GABA(A) receptors form Cl(−) permeable channels that mediate the majority of fast synaptic inhibition in the brain. The K(+)/Cl(−) cotransporter KCC2 is the main mechanism by which neurons establish low intracellular Cl(−) levels, which is thought to enable GABAergic inhibitory control of neuronal a...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Sivakumaran, Sudhir, Cardarelli, Ross A., Maguire, Jamie, Kelley, Matt R., Silayeva, Liliya, Morrow, Danielle H., Mukherjee, Jayanta, Moore, Yvonne E., Mather, Robert J., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Zicha, Stephen, Moss, Stephen J., Deeb, Tarek Z.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2015
Konular:
Brief Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444547/
https://ncbi.nlm.nih.gov/pubmed/26019342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5205-14.2015
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