Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu(5))

We report the discovery and SAR of two novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs). Exploration of several structural features in the western and eastern part of the imidazopyrimidinone core...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem Lett
Huvudupphovsmän: Martín-Martín, María Luz, Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Alonso de Diego, Sergio A., López, Silvia, Martínez-Viturro, Carlos M., Tong, Han Min, Lavreysen, Hilde, Macdonald, Gregor J., Steckler, Thomas, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Noetzel, Meredith J., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399811/
https://ncbi.nlm.nih.gov/pubmed/25683622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.038
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