Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu(5)) Receptor

Starting from a singleton chromanone high throughput screening (HTS) hit, we describe a focused medicinal chemistry optimization effort leading to the identification of a novel series of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metab...

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Detalhes bibliográficos
Main Authors: Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Delgado, Francisca, Iturrino, Laura, Pastor, Joaquín, Pena, Miguel Ángel, Trabanco, Andrés A., Tresadern, Gary, Wassvik, Carola M., Stauffer, Shaun R., Jadhav, Satyawan, Gogi, Kiran, Vinson, Paige N., Noetzel, Meredith J., Days, Emily, Weaver, C. David, Lindsley, Craig W., Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Rombouts, Frederik, Lavreysen, Hilde, Macdonald, Gregor J., Mackie, Claire, Steckler, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924858/
https://ncbi.nlm.nih.gov/pubmed/23947773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400650w
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