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Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
[Image: see text] Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu(5)) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicyclic dihydronaphthyridinone was i...
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| Autors principals: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2014
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096224/ https://ncbi.nlm.nih.gov/pubmed/24914612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500259z |
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