A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling

Metabotropic glutamate receptor 5 (mGlu(5)) is a target for the treatment of central nervous system (CNS) disorders, such as schizophrenia and Alzheimer’s disease. Furthermore, mGlu(5) has been shown to play an important role in hippocampal synaptic plasticity, specifically in long-term depression (...

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Main Authors: Noetzel, M. J., Gregory, K. J., Vinson, P. N., Manka, J. T., Stauffer, S. R., Lindsley, C. W., Niswender, C. M., Xiang, Z., Conn, P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608436/
https://ncbi.nlm.nih.gov/pubmed/23348500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082891
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