Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu(5): In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

Allosteric modulation of G protein-coupled receptors has gained considerable attention in the drug discovery arena because it opens avenues to achieve greater selectivity over orthosteric ligands. We recently identified a series of positive allosteric modulators (PAMs) of metabotropic glutamate rece...

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Detalhes bibliográficos
Main Authors: Blobaum, Anna L., Bridges, Thomas M., Byers, Frank W., Turlington, Mark L., Mattmann, Margrith E., Morrison, Ryan D., Mackie, Claire, Lavreysen, Hilde, Bartolomé, José M., MacDonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R., Daniels, J. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834130/
https://ncbi.nlm.nih.gov/pubmed/24003250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052662
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