A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo

Once thought to be an artifact of microsomal systems, atypical kinetics with cytochrome P450 (CYP) enzymes have been extensively investigated in vitro and found to be substrate and species dependent. Building upon increasing reports of heterotropic CYP activation and inhibition in clinical settings,...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Blobaum, Anna L., Byers, Frank W., Bridges, Thomas M., Locuson, Charles W., Conn, P. Jeffrey, Lindsley, Craig W., Daniels, J. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613951/
https://ncbi.nlm.nih.gov/pubmed/26265743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.064006
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