Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

Marketed drugs cleared by aldehyde oxidase (AO) are few, with no known clinically relevant pharmacokinetic drug interactions associated with AO inhibition, whereas cytochrome P450 (P450) inhibition or induction mediates a number of clinical drug interactions. Little attention has been given to the c...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Crouch, Rachel D., Morrison, Ryan D., Byers, Frank W., Lindsley, Craig W., Emmitte, Kyle A., Daniels, J. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Special Section on Emerging Novel Enzyme Pathways in Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986618/
https://ncbi.nlm.nih.gov/pubmed/26936972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068338
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