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Cytochromes P450 Catalyze the Reduction of α,β-Unsaturated Aldehydes
The metabolism of α,β-unsaturated aldehydes, e.g. 4-hydroxynonenal, involves oxidation to carboxylic acids, reduction to alcohols, and glutathionylation to eventually form mercapturide conjugates. Recently we demonstrated that P450s can oxidize aldehydes to carboxylic acids, a reaction previously th...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3180908/ https://ncbi.nlm.nih.gov/pubmed/21766881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200080b |
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