Cytochromes P450 catalyze oxidation of α,β-unsaturated aldehydes

We sought to establish whether heme-thiolate monooxygenases oxidize α,β-unsaturated aldehydes generated during lipid peroxidation. Several recombinant P450s co-expressed with NADPH:P450 oxidoreductase were surveyed for aldehyde oxidation activity with anthracene-9-carboxaldehyde and 4-hydroxy-trans-...

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Main Authors: Amunom, Immaculate, Stephens, Laura J., Tamasi, Viola, Cai, Jian, Conklin, Daniel J., Bhatnagar, Aruni, Srivastava, S., Martin, Martha V., Guengerich, F. Peter, Prough, Russell A.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994811/
https://ncbi.nlm.nih.gov/pubmed/17599801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.05.019
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