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Effect of Glutathione on Homo- and Heterotropic Cooperativity in Cytochrome P450 3A4
Glutathione (GSH) exerted a profound effect on the oxidation of 7-benzyloxy-4-(trifluoromethyl)coumarin (BFC) and 7-benzyloxyquinoline (BQ) by human liver microsomes as well as by CYP3A4-containing insect cell microsomes (Baculosomes). The cooperativity in O-debenzylation of both substrates is elimi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408553/ https://ncbi.nlm.nih.gov/pubmed/18206979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.01.001 |
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