Interactions among Cytochromes P450 in Microsomal Membranes: OLIGOMERIZATION OF CYTOCHROMES P450 3A4, 3A5, AND 2E1 AND ITS FUNCTIONAL CONSEQUENCES

The body of evidence of physiologically relevant P450-P450 interactions in microsomal membranes continues to grow. Here we probe oligomerization of human CYP3A4, CYP3A5, and CYP2E1 in microsomal membranes. Using a technique based on luminescence resonance energy transfer, we demonstrate that all thr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Davydov, Dmitri R., Davydova, Nadezhda Y., Sineva, Elena V., Halpert, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319048/
https://ncbi.nlm.nih.gov/pubmed/25533469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.615443
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