Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET)

The mechanisms of ligand binding and allostery in the major human drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) were explored with fluorescence resonance energy transfer (FRET) using a laser dye, fluorol-7GA (F7GA), as a model substrate. Incorporation into the enzyme of a thiol-reactive FRET...

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Main Authors: Davydov, Dmitri R., Rumfeldt, Jessica A. O., Sineva, Elena V., Fernando, Harshica, Davydova, Nadezhda Y., Halpert, James R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307279/
https://ncbi.nlm.nih.gov/pubmed/22194603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.325654
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