Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu(5): In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

Allosteric modulation of G protein-coupled receptors has gained considerable attention in the drug discovery arena because it opens avenues to achieve greater selectivity over orthosteric ligands. We recently identified a series of positive allosteric modulators (PAMs) of metabotropic glutamate rece...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Blobaum, Anna L., Bridges, Thomas M., Byers, Frank W., Turlington, Mark L., Mattmann, Margrith E., Morrison, Ryan D., Mackie, Claire, Lavreysen, Hilde, Bartolomé, José M., MacDonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R., Daniels, J. Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
Témata:
Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834130/
https://ncbi.nlm.nih.gov/pubmed/24003250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052662
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky