Use of a novel rapid and resource-efficient cassette dosing approach to determine the pharmacokinetics and CNS distribution of small molecule 7-transmembrane receptor allosteric mo...

Por Bridges, Thomas M, Morrison, Ryan D, Byers, Frank W, Luo, Shuanghui, Scott Daniels, J
Publicado em 2014

Synthesis and SAR of substituted pyrrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs

Por Wenthur, Cody J., Morrison, Ryan D., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2014

Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics

Por Raper, Jessica, Morrison, Ryan D., Daniels, J. Scott, Howell, Leonard, Bachevalier, Jocelyne, Wichmann, Thomas, Galvan, Adriana
Publicado no ACS Chem Neurosci (2017)

Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

Por Crouch, Rachel D., Morrison, Ryan D., Byers, Frank W., Lindsley, Craig W., Emmitte, Kyle A., Daniels, J. Scott
Publicado no Drug Metab Dispos (2016)

Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions

Por Rajapakse, Anuruddha, Linder, Collette, Morrison, Ryan D., Sarkar, Ujjal, Leigh, Nathan D., Barnes, Charles L., Daniels, J. Scott, Gates, Kent S.
Publicado em 2013

Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere

Por Downey, Jason D., Saleh, Sam A., Bridges, Thomas M., Morrison, Ryan D., Daniels, J. Scott, Lindsley, Craig W., Breyer, Richard M.
Publicado em 2012

Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys

Por Galvan, Adriana, Devergnas, Annaelle, Pittard, Damien, Masilamoni, Gunasingh, Vuong, Jocelyn, Daniels, J. Scott, Lindsley, Craig W., Morrison, Ryan D., Wichmann, Thomas
Publicado no ACS Chem Neurosci (2016)

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe

Por Delpire, Eric, Baranczak, Aleksandra, Waterson, Alex G., Kim, Kwangho, Kett, Nathan, Morrison, Ryan D., Daniels, J. Scott, Weaver, C. David, Lindsley, Craig W.
Publicado em 2012

Design, Synthesis and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethylbenzamides: Discovery of an Isoform-Selective Small Molecule P...

Por Lavieri, Robert R., Scott, Sarah A., Selvy, Paige E., Kim, Kwangho, Jadhav, Satyawan, Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.
Publicado em 2010

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1. Development of a potent and CNS penetrant [3.1.0]-based lead

Por Jones, Carrie K., Sheffler, Douglas J., Williams, Richard, Jadhav, Sataya B., Felts, Andrew S., Morrison, Ryan D., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2014

Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad spectrum antiviral activity against influenza strains

Por O’Reilly, Matthew C., Oguin, Thomas H., Scott, Sarah A., Thomas, Paul G., Locuson, Charles W., Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.
Publicado no ChemMedChem (2014)

Medication adherence, medical record accuracy, and medication exposure in real-world patients using comprehensive medication monitoring

Por Ryan, Timothy P., Morrison, Ryan D., Sutherland, Jeffrey J., Milne, Stephen B., Ryan, Kendall A., Daniels, J. Scott, Misra-Hebert, Anita, Hicks, J. Kevin, Vogan, Eric, Teng, Kathryn, Daly, Thomas M.
Publicado no PLoS One (2017)

Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)

Por Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

Synthesis and biological characterization of a series of novel diaryl amide M(1) antagonists

Por Poslusney, Michael S., Sevel, Christian, Utley, Thomas J., Bridges, Thomas M., Morrison, Ryan D., Kett, Nathan R., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. S., Conn, P. J., Lindsley, Craig W., Wood, Michael R.
Publicado em 2012

Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction

Por Amato, Russell J., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Jones, Carrie K., Emmitte, Kyle A.
Publicado em 2013

N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu(1): Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Por Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

N-Alkylpyrido[1′,2′:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu(1/5) with CNS exposure in rodents

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no Bioorg Med Chem Lett (2016)

Further optimization of the M(1) PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

Por Panarese, Joseph D., Cho, Hykeyung P., Adams, Jeffrey J., Nance, Kellie D., Garcia-Barrantes, Pedro M., Chang, Sichen, Morrison, Ryan D., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012

Por Melancon, Bruce J., Utley, Thomas J., Sevel, Christian, Mattmann, Margrith E., Cheung, Yiu-Yin, Bridges, Thomas M., Morrison, Ryan D., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2012

Chemical Modulation of Mutant mGlu(1) Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

Por Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Brogan, John T., Hopkins, Corey R., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Bubser, Michael, Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2014