Design, Synthesis and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethylbenzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 (PLD2) Inhibitor

Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Two mammalian isoforms of PLD have been identified, PLD1 and PLD2, which share 53% sequence identity and are subject to different regulatory mechanisms. Inhibition of PLD enzymatic...

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Detalhes bibliográficos
Main Authors: Lavieri, Robert R., Scott, Sarah A., Selvy, Paige E., Kim, Kwangho, Jadhav, Satyawan, Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179181/
https://ncbi.nlm.nih.gov/pubmed/20735042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100814g
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