Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity

This Letter describes the synthesis and structure–activity relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of a 1,3,8-triazaspiro[4,5]decan-4-one privileged structure, PLD inhibitors with nanomolar potency and an unprecedented 40-fold selectivity for PLD2 over...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Lavieri, Robert, Scott, Sarah A., Lewis, Jana A., Selvy, Paige E., Armstrong, Michelle D., Brown, H. Alex, Lindsley, Craig W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800051/
https://ncbi.nlm.nih.gov/pubmed/19299128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.02.125
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia