Use of a novel rapid and resource-efficient cassette dosing approach to determine the pharmacokinetics and CNS distribution of small molecule 7-transmembrane receptor allosteric mo...

Por Bridges, Thomas M, Morrison, Ryan D, Byers, Frank W, Luo, Shuanghui, Scott Daniels, J
Publicado em 2014

Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

Por Crouch, Rachel D., Morrison, Ryan D., Byers, Frank W., Lindsley, Craig W., Emmitte, Kyle A., Daniels, J. Scott
Publicado no Drug Metab Dispos (2016)

A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytoc...

Por Blobaum, Anna L., Byers, Frank W., Bridges, Thomas M., Locuson, Charles W., Conn, P. Jeffrey, Lindsley, Craig W., Daniels, J. Scott
Publicado no Drug Metab Dispos (2015)

Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu(3) Selective and CNS Penetrant Negative Allosteric Modulator (NA...

Por Wenthur, Cody J., Morrison, Ryan, Felts, Andrew S., Smith, Katrina A., Engers, Julie L., Byers, Frank W., Daniels, J. Scott, Emmitte, Kyle A., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2013

Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no Bioorg Med Chem Lett (2018)

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu(1)), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)...

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Niswender, Colleen M., Byers, Frank W., Locuson, Charles W., Blobaum, Anna L., Xiang, Zixiu, Rook, Jerri M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no J Med Chem (2015)

Further optimization of the M(5) NAM MLPCN probe ML375: Tactics and challenges

Por Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2014)

Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction

Por Amato, Russell J., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Jones, Carrie K., Emmitte, Kyle A.
Publicado em 2013

N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu(1): Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Por Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

N-Alkylpyrido[1′,2′:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu(1/5) with CNS exposure in rodents

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no Bioorg Med Chem Lett (2016)

Discovery of VU0409106: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

Discovery of VU0431316: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety

Por Bates, Brittney S., Rodriguez, Alice L., Felts, Andrew S., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Lawson, Kera P., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2014

Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Bollinger, Katrina A., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Gray, Analisa Thompson, Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no Bioorg Med Chem Lett (2017)

Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

Por Felts, Andrew S., Rodriguez, Alice L., Smith, Katrina A., Engers, Julie L., Morrison, Ryan D., Byers, Frank W., Blobaum, Anna L., Locuson, Charles W., Chang, Sichen, Venable, Daryl F., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2015)

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Por Engers, Julie L., Rodriguez, Alice L., Konkol, Leah C., Morrison, Ryan D., Thompson, Analisa D., Byers, Frank W., Blobaum, Anna L., Chang, Sichen, Venable, Daryl F., Loch, Matthew T., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2015)

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu(5): In Vitro to In Vivo Translation and Potential Impact on Clinic...

Por Blobaum, Anna L., Bridges, Thomas M., Byers, Frank W., Turlington, Mark L., Mattmann, Margrith E., Morrison, Ryan D., Mackie, Claire, Lavreysen, Hilde, Bartolomé, José M., MacDonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R., Daniels, J. Scott
Publicado em 2013

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

Por Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Bertron, Jeanette, Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2017)

Partial mGlu(5) Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects

Por Gould, Robert W, Amato, Russell J, Bubser, Michael, Joffe, Max E, Nedelcovych, Michael T, Thompson, Analisa D, Nickols, Hilary H, Yuh, Johannes P, Zhan, Xiaoyan, Felts, Andrew S, Rodriguez, Alice L, Morrison, Ryan D, Byers, Frank W, Rook, Jerri M, Daniels, John S, Niswender, Colleen M, Conn, P Jeffrey, Emmitte, Kyle A, Lindsley, Craig W, Jones, Carrie K
Publicado no Neuropsychopharmacology (2016)

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Sel...

Por Felts, Andrew S., Rodriguez, Alice L., Blobaum, Anna L., Morrison, Ryan D., Bates, Brittney S., Thompson Gray, Analisa, Rook, Jerri M., Tantawy, Mohammed N., Byers, Frank W., Chang, Sichen, Venable, Daryl F., Luscombe, Vincent B., Tamagnan, Gilles D., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2017)

The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

Por Morrison, Ryan D., Blobaum, Anna L., Byers, Frank W., Santomango, Tammy S., Bridges, Thomas M., Stec, Donald, Brewer, Katrina A., Sanchez-Ponce, Raymundo, Corlew, Melany M., Rush, Roger, Felts, Andrew S., Manka, Jason, Bates, Brittney S., Venable, Daryl F., Rodriguez, Alice L., Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A., Daniels, J. Scott
Publicado em 2012